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Chinese Physics C> 2012, Vol. 36> Issue(8) : 784-791 DOI: 10.1088/1674-1137/36/8/018

Active spot-scanning test with heavy ions at HIRFL-CSR

  • An active spot beam delivery system for heavy ion therapy has been developed based on the Cooling Storage Ring at HIRFL-CSR, where the pencil carbon-ion beams were scanned within a target volume transversely by a pair of orthogonal (horizontal and vertical) dipole magnets to paint the slices of the target volume and longitudinally by active energy variation of the synchrotron slice by slice. The unique techniques such as dose shaping via active energy variation and magnetic deflection constitute a promising three-dimensional conformal even intensity-modulated radiotherapy with heavy ions at HIRFL-CSR. In this paper, the verification of active energy variation and the calibration of steerable beam deflection are shown, as the basic functionality components of the active spot-scanning system. Additionally, based on the capability of creating homogeneous irradiation fields with steerable pencil beams, a radiobiological experiment like cell survival measurement has been performed aiming at comparison of the radiobiological effects under active and passive beam deliveries.

  • References

    [1] Ahlen S P. Reviews of Modern Physics, 1980, 52: 121[2] Haberer T, Becher W, Schardt D, Kraft G. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1993, 330(1-2): 296-305[3] Wilson RR. Radiology, 1946, 47(5): 487-491[4] Kanai T, Kawachi K, Matsuzawa H, Inada T. Nuclear Instruments and Methods in Physics Research, 1983, 214(2-3): 491-496[5] Pedroni E, Blattmann H, B hringer T, Coray A, Lin S, Scheib S, Schneider U. Voxel Scanning for Proton Therapy. the NIRS International Workshop on Heavy Charged Particle Therapy and Related Subjects. Proc. of the NIRS International Workshop on Heavy Charged Particle Therapy and Related Subjects. 1991, 94-109[6] Scheib S, Pedroni E. Radiation and Environmental Biophysics, 1992, 31(3): 251-256[7] Kraft G, Arndt U, Becher W, Schardt D, Stelzer H, Weber U, Archinal T. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1995, 367(1-3): 66-70[8] Pedroni E, Bacher R, Blattmann H, B hringer T, Coray A, Lomax A, Lin S, Munkel G, Scheib S, Schneider U. Medical Physics, 1995, 22: 37[9] Noda K, Furukawa T, Fujisawa T, Iwata Y, Kanai T, Kanazawa M, Kitagawa A, Komori M, Minohara S, Murakami T. Journal of Radiation Research, 2007, 48(Suppl. A): 43-54[10] LI Q, WEI Z Q, LI W J. Chinese Science Bulletin, 2002, 47(20): 1708-1710[11] DAI Z Y, LI Q. High Energy Physics and Nuclear Physics, 2007, 31(7): 655-659 (in Chinese)[12] LI Q, DAI Z Y, YAN Z, JIN X D, LIU X G, XIAO G Q. Medical and Biological Engineering and Computing, 2007, 45(11): 1037-1043[13] HUANG Y Z, GAO D Q. Atomic Energy Science and Technology, 2009, 9: 4[14] Schardt D, Elssser T, Schulz-Ertner D. Reviews of Modern Physics, 2010, 82(1): 383-425[15] Jakel O, Schulz-Ertner D, Karger C P, Nikoghosyan A, Debus J. Technology in Cancer Research and Treatment, 2003, 2(5): 377-388[16] Sihver L, Mancusi D. Radiation Measurements, 2009, 44(1): 38-46[17] Urakabe E, Kanai T, Kanazawa M, Kitagawa A, Noda K, Tomitani T, Suda M, Iseki Y, Hanawa K, Sato K. Jpn. J Appl. Phys., 2001, 40: 2540-2548[18] Kramer M, Jkel O, Haberer T, Kraft G, Schardt D, Weber U. Physics in Medicine and Biology, 2000, 45: 3299-3317[19] Lomax A. Physics in Medicine and Biology, 1999, 44: 185

  • References

    [1] Ahlen S P. Reviews of Modern Physics, 1980, 52: 121[2] Haberer T, Becher W, Schardt D, Kraft G. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1993, 330(1-2): 296-305[3] Wilson RR. Radiology, 1946, 47(5): 487-491[4] Kanai T, Kawachi K, Matsuzawa H, Inada T. Nuclear Instruments and Methods in Physics Research, 1983, 214(2-3): 491-496[5] Pedroni E, Blattmann H, B hringer T, Coray A, Lin S, Scheib S, Schneider U. Voxel Scanning for Proton Therapy. the NIRS International Workshop on Heavy Charged Particle Therapy and Related Subjects. Proc. of the NIRS International Workshop on Heavy Charged Particle Therapy and Related Subjects. 1991, 94-109[6] Scheib S, Pedroni E. Radiation and Environmental Biophysics, 1992, 31(3): 251-256[7] Kraft G, Arndt U, Becher W, Schardt D, Stelzer H, Weber U, Archinal T. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1995, 367(1-3): 66-70[8] Pedroni E, Bacher R, Blattmann H, B hringer T, Coray A, Lomax A, Lin S, Munkel G, Scheib S, Schneider U. Medical Physics, 1995, 22: 37[9] Noda K, Furukawa T, Fujisawa T, Iwata Y, Kanai T, Kanazawa M, Kitagawa A, Komori M, Minohara S, Murakami T. Journal of Radiation Research, 2007, 48(Suppl. A): 43-54[10] LI Q, WEI Z Q, LI W J. Chinese Science Bulletin, 2002, 47(20): 1708-1710[11] DAI Z Y, LI Q. High Energy Physics and Nuclear Physics, 2007, 31(7): 655-659 (in Chinese)[12] LI Q, DAI Z Y, YAN Z, JIN X D, LIU X G, XIAO G Q. Medical and Biological Engineering and Computing, 2007, 45(11): 1037-1043[13] HUANG Y Z, GAO D Q. Atomic Energy Science and Technology, 2009, 9: 4[14] Schardt D, Elssser T, Schulz-Ertner D. Reviews of Modern Physics, 2010, 82(1): 383-425[15] Jakel O, Schulz-Ertner D, Karger C P, Nikoghosyan A, Debus J. Technology in Cancer Research and Treatment, 2003, 2(5): 377-388[16] Sihver L, Mancusi D. Radiation Measurements, 2009, 44(1): 38-46[17] Urakabe E, Kanai T, Kanazawa M, Kitagawa A, Noda K, Tomitani T, Suda M, Iseki Y, Hanawa K, Sato K. Jpn. J Appl. Phys., 2001, 40: 2540-2548[18] Kramer M, Jkel O, Haberer T, Kraft G, Schardt D, Weber U. Physics in Medicine and Biology, 2000, 45: 3299-3317[19] Lomax A. Physics in Medicine and Biology, 1999, 44: 185

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DAI Zhong-Ying, LI Qiang, LIU Xin-Guo, JIN Xiao-Dong, HUANG Qi-Yan and XIAO Guo-Qing. Active spot-scanning test with heavy ions at HIRFL-CSR[J]. Chinese Physics C, 2012, 36(8): 784-791. doi: 10.1088/1674-1137/36/8/018
DAI Zhong-Ying, LI Qiang, LIU Xin-Guo, JIN Xiao-Dong, HUANG Qi-Yan and XIAO Guo-Qing. Active spot-scanning test with heavy ions at HIRFL-CSR[J]. Chinese Physics C, 2012, 36(8): 784-791.  doi: 10.1088/1674-1137/36/8/018 shu
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Received: 2011-11-22
Revised: 1900-01-01
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Active spot-scanning test with heavy ions at HIRFL-CSR

    Corresponding author: LI Qiang,
  • Received Date: 2011-11-22
  • Accepted Date: 1900-01-01
  • Available Online: 2012-08-05

Abstract: An active spot beam delivery system for heavy ion therapy has been developed based on the Cooling Storage Ring at HIRFL-CSR, where the pencil carbon-ion beams were scanned within a target volume transversely by a pair of orthogonal (horizontal and vertical) dipole magnets to paint the slices of the target volume and longitudinally by active energy variation of the synchrotron slice by slice. The unique techniques such as dose shaping via active energy variation and magnetic deflection constitute a promising three-dimensional conformal even intensity-modulated radiotherapy with heavy ions at HIRFL-CSR. In this paper, the verification of active energy variation and the calibration of steerable beam deflection are shown, as the basic functionality components of the active spot-scanning system. Additionally, based on the capability of creating homogeneous irradiation fields with steerable pencil beams, a radiobiological experiment like cell survival measurement has been performed aiming at comparison of the radiobiological effects under active and passive beam deliveries.

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