Neutron beam optimization based on a 7Li(p,n)7Be reaction for treatment of deep-seated brain tumors by BNCT

Zahra Ahmadi Ganjeh; S. Farhad Masoudi

doi:10.1088/1674-1137/38/10/108203

Chinese Physics C> 2014, Vol. 38> Issue(10) : 108203 DOI: 10.1088/1674-1137/38/10/108203

Neutron beam optimization based on a ⁷Li(p,n)⁷Be reaction for treatment of deep-seated brain tumors by BNCT

Zahra Ahmadi Ganjeh ,
S. Farhad Masoudi ^,

Abstract
HTML
Reference
Related

PDF

Abstract：
Neutron beam optimization for accelerator-based Boron Neutron Capture Therapy (BNCT) is investigated using a ⁷Li(p,n)⁷Be reaction. Design and optimization have been carried out for the target, cooling system, moderator, filter, reflector, and collimator to achieve a high flux of epithermal neutron and satisfy the IAEA criteria. Also, the performance of the designed beam in tissue is assessed by using a simulated Snyder head phantom. The results show that the optimization of the collimator and reflector is critical to finding the best neutron beam based on the ⁷Li(p,n)⁷Be reaction. Our designed beam has 2.49×10⁹n/cm²s epithermal neutron flux and is suitable for BNCT of deep-seated brain tumors.

References

[1]

Bleuel D L, Donahue R J, Ludewigt B A, Vujic J. Med. Phys., 1998, 25: 1725-1734[2] Sakamoto S, Kiger W S, Harling O K. Med. Phys., 1999, 26: 1979-1998[3] Lee C L, ZHOU X L. Methods Phys. Res. B, 1999, 152: 1-11[4] Montagnini B, Cerullo N, Esposito J, Giustia V et al. Phys. Res. A, 2002, 476: 90-98[5] Blue T E, Yanch J C. J. Neuro-Onco., 2003, 62: 19-31[6] Burlon A A, Kreiner A J. Nucl. Instrum. Methods Phys. Res. B, 2008, 266: 763-771[7] Salehi D, Sardari D, Salehi Jozani M. Chinese Phys. C, 2013, 37: 078201[8] CHENG D W, LU J B, YANG D et al. Chinese Phys. C, 2012, 36: 905[9] IAEA-TECDOC-1223, 2001, International Atomic Energy Agency, 2001[10] Randers G, Brenner D J, Med. Phys., 1998, 25: 894-896[11] Bayanov B, Belov V, Kindyuk V et al. Appl. Radiat. Isot., 2004, 61: 817-821[12] KIM J K, KIM K O. Nucl. Eng. Technol., 2009, 41: 531-544[13] Tanaka K, Yokobori H, Kobayashi E et al. Appl. Radiat. Isot., 2009, 67: 259-265[14] Incropera F P, DeWitt P D. Introduction to Heat Transfer. 4th ed. Published: New York: Wiley, 2002[15] Rasouli F S, Masoudi S F, Kasesaz Y. Ann. Nucl. Energy., 2012, 39: 18-25[16] Rahmani F, Shahriari M. Ann. Nucl. Energy, 2011, 38: 404-409[17] Durisi E, Zanini A, Manfredotti C et al. Nucl. Instrum. Methods Phys. Res. A, 2007, 574: 363-369[18] Herrera M S, Gonzalez S J, Minsky D M et al. Phys. Med., 2013, 29: 436-449

[1]	A. Morzabayev , N. Amangeldi , Awad A. Ibraheem , D. Soldatkhan , G. Yergaliuly , B. Mauyey , Anuar. A. Orazalievna , Sh. Hamada . Dynamics of ⁷Li breakup and its influence on elastic scattering: a study of ⁷Li + ¹⁴⁴Sm system. Chinese Physics C, 2024, 48(2): 024103. doi: 10.1088/1674-1137/ad1029
[2]	Haoyu Jiang , Wei Jiang , Huaiyong Bai , Zengqi Cui , Guohui Zhang , Ruirui Fan , Han Yi , Changjun Ning , Liang Zhou , Jingyu Tang , Qi An , Jie Bao , Yu Bao , Ping Cao , Haolei Chen , Qiping Chen , Yonghao Chen , Yukai Chen , Zhen Chen , Changqing Feng , Keqing Gao , Minhao Gu , Changcai Han , Zijie Han , Guozhu He , Yongcheng He , Yang Hong , Hanxiong Huang , Weiling Huang , Xiru Huang , Xiaolu Ji , Xuyang Ji , Zhijie Jiang , Hantao Jing , Ling Kang , Mingtao Kang , Bo Li , Chao Li , Jiawen Li , Lun Li , Qiang Li , Xiao Li , Yang Li , Rong Liu , Shubin Liu , Xingyan Liu , Guangyuan Luan , Qili Mu , Binbin Qi , Jie Ren , Zhizhou Ren , Xichao Ruan , Zhaohui Song , Yingpeng Song , Hong Sun , Kang Sun , Xiaoyang Sun , Zhijia Sun , Zhixin Tan , Hongqing Tang , Xinyi Tang , Binbin Tian , Lijiao Wang , Pengcheng Wang , Qi Wang , Taofeng Wang , Zhaohui Wang , Jie Wen , Zhongwei Wen , Qingbiao Wu , Xiaoguang Wu , Xuan Wu , Likun Xie , Yiwei Yang , Li Yu , Tao Yu , Yongji Yu , Linhao Zhang , Qiwei Zhang , Xianpeng Zhang , Yuliang Zhang , Zhiyong Zhang , Yubin Zhao , Luping Zhou , Zuying Zhou , Danyang Zhu , Kejun Zhu , Peng Zhu . Measurements of differential and angle-integrated cross sections for the ¹⁰B(n, α)⁷Li reaction in the neutron energy range from 1.0 eV to 2.5 MeV. Chinese Physics C, 2019, 43(12): 124002. doi: 10.1088/1674-1137/43/12/124002
[3]	Er-Tao Li , Zhi-Hong Li , Sheng-Quan Yan , Jun Su , Bing Guo , Yun-Ju Li , You-Bao Wang , Gang Lian , Sheng Zeng , Si-Zhe Chen , Shao-Bo Ma , Xiang-Qing Li , Cao He , Hui-Bin Sun , Wei-Ping Liu . Measurement of the ²H(⁷Be, ⁶Li) ³He reaction rate and its contribution to the primordial lithium abundance. Chinese Physics C, 2018, 42(4): 044001. doi: 10.1088/1674-1137/42/4/044001
[4]	Zhi-Hong Li , Er-Tao Li , Jun Su , Yun-Ju Li , You-Bao Wang , Sheng-Quan Yan , Bing Guo , Ding Nan , Wei-Ping Liu . New determination of the ⁷Be ground state spectroscopic factor and the ⁶Li(p,γ)⁷Be astrophysical S(E) factors. Chinese Physics C, 2018, 42(6): 065001. doi: 10.1088/1674-1137/42/6/065001
[5]	Li Zhang , Yun-Chong Fu . Preliminary study of ¹⁰Be/⁷Be in rainwater from Xi'an by Accelerator Mass Spectrometry. Chinese Physics C, 2017, 41(1): 018201. doi: 10.1088/1674-1137/41/1/018201
[6]	LIU Lang . Ab initio Monte Carlo shell model calculations for ⁷Li and ⁹Li low-lying spectra. Chinese Physics C, 2015, 39(6): 064101. doi: 10.1088/1674-1137/39/6/064101
[7]	YANG Xiao-Peng , YU Bo-Xiang , LI Yi-Guo , PENG Dan , LU Jin , ZHANG Gao-Long , ZHAO Hang , ZHANG Ai-Wu , LI Chun-Yang , LIU Wan-Jin , HU Tao , . Neutron collimator design of neutron radiography basedon the BNCT facility. Chinese Physics C, 2014, 38(2): 028201. doi: 10.1088/1674-1137/38/2/028201
[8]	CHENG Dao-Wen , LU Jing-Bin , YANG Dong , LIU Yu-Min , WANG Hui-Dong , MA Ke-Yan . Designing of the 14 MeV neutron moderator for BNCT. Chinese Physics C, 2012, 36(9): 905-908. doi: 10.1088/1674-1137/36/9/020
[9]	PU Zhong-Sheng , FAN Kang-Kang , SONG Guan-Qiang . Cross section measurements for (n, p) reaction on stannum isotopes at neutron energies from 13.5 to 14.6 MeV. Chinese Physics C, 2011, 35(5): 445-448. doi: 10.1088/1674-1137/35/5/007
[10]	HOU Pei-You , SUN Xiao-Jun , YU Cheng-Gang , LU Xiao . Theoretical analysis of double-differential neutron emission cross sections for n+⁵⁶Fe reactions at incident energies of 7-13 MeV. Chinese Physics C, 2011, 35(1): 35-39. doi: 10.1088/1674-1137/35/1/008
[11]	LI Guang-Shun , ZHOU Xiao-Hong , ZHANG Yu-Hu , HUA Wei , WANG Shi-Tao , DING Bing , WANG Hai-Xia , Oshima M , Toh Y , Koizumi M , Osa A , Hatsukawa Y , Sugawara M . Properties of the ν7/2^-[503](f_7/2) band in ¹⁸⁵Pt. Chinese Physics C, 2011, 35(5): 441-444. doi: 10.1088/1674-1137/35/5/006
[12]	ZHOU Jian-Rong , SUN Zhi-Jia , LIU Ben , WANG Yan-Feng , YANG Gui-An , ZHOU Liang , XU Hong , DONG Jing , YANG Lei , LI Yi . Neutron beam monitor based on a boron-coated GEM. Chinese Physics C, 2011, 35(7): 668-674. doi: 10.1088/1674-1137/35/7/012
[13]	Jang Bo , Suk Lee , Sam Ju , Sang Hoon , Juree Kim , Kwang Hwan , Chul Kee , Hyun Do , Rena Lee , Dae Sik , Young Je , Won Seob , Chul Yong , Soo Il . Comparison of linac-based fractionated stereotactic radiotherapy and tomotherapy treatment plans for intra-cranial tumors. Chinese Physics C, 2010, 34(11): 1768-1774. doi: 10.1088/1674-1137/34/11/020
[14]	RUAN Xi-Chao , ZHOU Zu-Ying , CHEN Guo-Chang , QI Bu-Jia , LI Xia , HUANG Han-Xiong , ZHONG Qi-Ping , TANG Hong-Qing , JIANG Jing , XIN Biao , BAO Jie , CHEN Lin , ZHANG Jing-Shang . Measurements of Neutron Emission Spectra for Neutron Induced Reactions on ⁹Be and ^6,7Li. Chinese Physics C, 2007, 31(5): 442-447.
[15]	SUI Li , ZHAO Kui , NI Mei-Nan , GUO Ji-Yu , LUO Hong-Bing , MEI Jun-Ping , LU Xiu-Qin , ZHOU Ping . Investigation of DNA Strand Breaks Induced by ⁷Li and ¹²C Ions. Chinese Physics C, 2004, 28(10): 1126-1130.
[16]	YE Zi-Piao , HU Bao-Jian , KUANG Hao-Huai . Computation of ⁷Be Electron-Capture Rate in the Solar Interior. Chinese Physics C, 2002, 26(1): 17-20.
[17]	ZHOU Shu-Hua , ZHU Li-Hua , XIA Hai-Hong , ZHU Xiao-Feng , WU Xiao-Guang , HOU Long , YANG Chun-Xiang , LIU Zu-Hua . Experimental Study of Spin-Flip M1 Transition of ⁷_ΛLi. Chinese Physics C, 2000, 24(S1): 81-86.
[18]	CHEN FENG-ZHI , HAO CHUN . THE CP VIOLATION OF SU(7) MODEL. Chinese Physics C, 1982, 6(1): 30-35.
[19]	HAN WEN-SHU , LU ZHAO-QI , ZHUANG FEI , ZHENG YU-MING . THE MOMENTUM DISTRIBUTION OF THE NUCLEAR CLUSTER FOR ^6,7Li NUCLEI. Chinese Physics C, 1981, 5(4): 489-492.
[20]	LIAO JI-ZHI . SHELL MODEL CALCULATIONS ON 1f_7/2 NUCLEI. Chinese Physics C, 1979, 3(6): 734-748.

Access

Get Citation

Zahra Ahmadi Ganjeh and S. Farhad Masoudi. Neutron beam optimization based on a ⁷Li(p,n)⁷Be reaction for treatment of deep-seated brain tumors by BNCT[J]. Chinese Physics C, 2014, 38(10): 108203. doi: 10.1088/1674-1137/38/10/108203

RIS(for EndNote,Reference Manager,ProCite)

BibTex

Txt

Milestone

Received: 2013-11-04
Revised: 1900-01-01

Article Metric

Article Views(1723)
PDF Downloads(149)
Cited by(0)

Policy on re-use

To reuse of subscription content published by CPC, the users need to request permission from CPC, unless the content was published under an Open Access license which automatically permits that type of reuse.

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Neutron beam optimization based on a ⁷Li(p,n)⁷Be reaction for treatment of deep-seated brain tumors by BNCT

Corresponding author: S. Farhad Masoudi,

Received Date: 2013-11-04

Accepted Date: 1900-01-01

Available Online: 2014-10-05

Abstract: Neutron beam optimization for accelerator-based Boron Neutron Capture Therapy (BNCT) is investigated using a ⁷Li(p,n)⁷Be reaction. Design and optimization have been carried out for the target, cooling system, moderator, filter, reflector, and collimator to achieve a high flux of epithermal neutron and satisfy the IAEA criteria. Also, the performance of the designed beam in tissue is assessed by using a simulated Snyder head phantom. The results show that the optimization of the collimator and reflector is critical to finding the best neutron beam based on the ⁷Li(p,n)⁷Be reaction. Our designed beam has 2.49×10⁹n/cm²s epithermal neutron flux and is suitable for BNCT of deep-seated brain tumors.

HTML

Reference (1)

Neutron beam optimization based on a ⁷Li(p,n)⁷Be reaction for treatment of deep-seated brain tumors by BNCT

Abstract：

References

Access

Article Metrics

Metrics

通讯作者: 陈斌, bchen63@163.com

Email This Article

Neutron beam optimization based on a ⁷Li(p,n)⁷Be reaction for treatment of deep-seated brain tumors by BNCT

Corresponding author: S. Farhad Masoudi,

HTML

目录