Measurements of 41Ca in Biological Samples by AMS Using CaF2 Target

LI Shi-Hong; JIANG Shan; HE Ming; GUAN Yong-Jing; DONG Ke-Jun; WU Shao-Yong; YUAN Yuan; MI Sheng-Quan; LIU Shu-Tian; YUAN Jian

Chinese Physics C> 2005, Vol. 29> Issue(12) : 1210-1213

Measurements of 41Ca in Biological Samples by AMS Using CaF2 Target

Department of Nuclear Physics,Chinese Institute of Atomic Energy,Beijing 102413,China

Abstract
HTML
Reference
Related

PDF

Abstract：
For determining numbers of ⁴¹Ca labeled biological samples, the analytical method of ⁴¹Ca/⁴⁰Ca by Accelerator Mass Spectrometry (AMS) using CaF₂ target was developed at the Beijing HI-13 AMS system. ⁴¹Ca in the biological samples and ⁴¹Ca standard samples were prepared to CaF₂ with a more effective chemical separation and purification procedure. In the ⁴¹Ca AMS measurement, CaF₃^－ negative ion was extracted from ion resource, 7⁺ charge state of particles was chosen after carbon foil stripping and accelerated at 8.5MV terminal voltage. ⁴¹Ca ions were finally recorded by an 140mbar P10 gas filled multi-anode ionization chamber detector. The results showed that ⁴¹Ca and the main isobar, ⁴¹K could be clearly identified in the two-dimensional density spectra, and the interference of ⁴¹K to ⁴¹Ca was eliminated with the very low ⁴¹K counting rate. The absolute measured values of 4 standard samples with ⁴¹Ca/⁴⁰Ca in the range of 1.785×10^－8—1.750×10^－10 were in good linear relationship with the standard values (r²=0.997). After normalized with the 1.785×10^－8⁴¹Ca/⁴⁰Ca standard, the measured values of S2 and S4 standard samples were in good agreement with the nominal values, however, the measured value of S3 deviated the nominal value largely. The ⁴¹Ca/⁴⁰Ca of the biological blanks were estimated below 8.2×10^－13.

References

[1]

. Johnson R R, Berkovits D, Boaretto E et al. Nucl. Instrum.Methods, 1994, B92: 483—4882. Freeman S P H T, Beck B, Bierman J M et al. Nucl. In-strum. Methods, 2000, B172: 930—9333. JIANG Shan, HE Ming, DONG Ke-Jun et al. Nucl. In-strum. Methods, 2004, B223/224: 750—7534. Fink D, Middleton R, Klein J et al. Nucl. Instrum. Meth-ods. Phys. Res., 1990, B47: 79—965. Freeman S P H T, Serfass R E, King J C et al. Nucl. In-strum. Methods. Phys. Res., 1995, B99: 557—5616. DONG Ke-Jun, HE Ming, WU Shao-Yong et al. ChinesePhys. Lett., 2004, 21(1): 51—537. YUE Dong-Fang, DONG Ke-Jun, HE Ming et al. Atom.Energy Sci. and Tech., 2004, 38(3): 271—274(in Chinese)(岳东方，董克君，何明等.原子能科学技术，2004, 38(3):271-274)8. WU Shao-Yong, JIANG Shan, DONG Ke-Jun et al. J.Chin. Mass Spectr. Soc., 2002, 23(4): 248—251(in Chinese)(武绍勇，姜山，董克君等.质谱学报，2002, 23(4): 248-251)

[1]	HUANG Guo-Qing , YE Kai-Rong . Beam Measurement Using Digital Technology. Chinese Physics C, 2008, 32(S1): 142-144.
[2]	ZHAN Tian-Wen , LIU Jin-Liang , GE Bing , YIN Yi . Preliminary Research on Primary Energy Source of High Current Electron Beam Accelerator Based on Spiral Pulse Forming Line. Chinese Physics C, 2008, 32(S1): 295-297.
[3]	YIN Xin-Yi , HE Ming , DONG Ke-Jun , QIU Jiu-Zi , WU Shao-Yong , ZHANG Jin-Song , ZHANG Chun-Hua , ZHENG Yun , GUAN Yong-Jing , JIANG Shan . Preparation of ¹⁸²Hf AMS Standard Sample and Test on HI-13 Tandem AMS. Chinese Physics C, 2007, 31(10): 978-981.
[4]	QIU Jiu-Zi , JIANG Shan , HE Ming , YIN Xin-Yi , DONG Ke-Jun , GUAN Yong-Jing , WU Shao-Yong . Research on Measurement of ¹⁸²Hf with HI-13 AMS System. Chinese Physics C, 2007, 31(8): 719-723.
[5]	YANG Xue-Qing , FANG Jia-Xun , GUO Zhi-Yu , CHEN Jia-Rong . Matching Design Method for High Intensity RFQ Accelerators. Chinese Physics C, 2006, 30(S1): 19-21.
[6]	YU Hai-Jun , LI Yu-Xiong , SHI Jin-Shui , LI Qin , CHEN Nan . Experimental Measurement of X-ray Energy Spectrum for 12 MeV LIA. Chinese Physics C, 2006, 30(S1): 90-92.
[7]	YAO Jiang-Ming , MENG Jie , PENG Jing . Time-Odd Component and its Influence on the Properties of ⁴¹Ca. Chinese Physics C, 2006, 30(8): 750-754.
[8]	KONG Xiao-Xiao , ZHAO Hong-Bin , LI Quan-Feng , LIN Xiao-Qi . A Method to Increase the Dose Rate of Medical Linear Electron Accelerators by Considering the Target and the Flattening Filter as a Whole System When Designing the Target. Chinese Physics C, 2005, 29(9): 903-906.
[9]	YU Neng-Jie , TANG Chuan-Xiang , ZHENG Shu-Xin , LI Quan-Feng , GONG Ke . 2-D Beam Profile Measurement Based on CT Algorithm with Rotating Multi-Wire Target. Chinese Physics C, 2005, 29(4): 408-412.
[10]	YING Jun , BAN Yong , YE Yan-Lin , CAI Jian-Xin , QIAN Si-Jin , WANG Quan-Jin , LIU Hong-Tao . Beam Test Results of the First Full-Scale Prototype of CMS RE1/2 Resistive Plate Chamber. Chinese Physics C, 2005, 29(2): 175-179.
[11]	WAN Jun-Sheng , ZHANG Ying , ZHANG Li-Xing , YU Hong-Wei , XIA Hai-Hong , DING Da-Zhao . Studies on Optimization of Solid W-Target in Accelerator-Driven System. Chinese Physics C, 2003, 27(6): 537-541.
[12]	WANG Shun-Jin , GUO Yuan-Jun . Complementary Chaos and Spin Polarization Stability in Cyclotrons Studied from the Nonautonomous SU(2)Dynamical System. Chinese Physics C, 2003, 27(12): 1123-1127.
[13]	SHENG Xiang-Dong , DAI Chang-Jiang , HE Hui-Lin . Experimental Research on the New. Chinese Physics C, 2002, 26(3): 273-278.
[14]	MING Zhao-Yu , ZHANG Feng-Shou , CHEN Lie-Wen , ZHU Zhi-Yuan . Radial Expansion Flow in Reactions of ⁴⁰Ca+⁵⁸Fe and ⁴⁰Ca+⁵⁸Ni. Chinese Physics C, 2001, 25(6): 549-554.
[15]	REN XiaoTang , Lu YuanRong , YU JinXiang , WANG ZhongYi , LI WeiGuo , GUO JuFang , SONG ZhiZhong , LI YuSong , FANG JiaXun , CHEN JiaEr . Experimental Research on Simultaneous Acceleration of Positive and Negative Ions with Equal q/m in an ISR RFQ. Chinese Physics C, 2000, 24(4): 347-351.
[16]	Sha Yin , Liu Zhuhua , Li Wugui , Zhang Caixia , Yang Zhenjun , Gong Jianhua , Wang Xin , Luo Bo . Improvements and Status of the Proton Electrostatic Accelerator, V2. Chinese Physics C, 1999, 23(6): 573-578.
[17]	Liu Lianfan , Cheng Xiaowu , Zhou Weinan , Hu Miaojun , Sun Guoyan , Wang Naxiu . Formation Cross Section of ¹⁰Be Measured by Accelerator Mass Spectrometry Technique. Chinese Physics C, 1995, 19(9): 786-790.
[18]	FAN Qin-Min , Zhong Ming . THE NUMERICAL CALCULATION USED IN THICK TARGET PIXE ANALYSES. Chinese Physics C, 1988, 12(1): 6-11.
[19]	XU Jian-Ming , LIU Shi-Yao . A PROPOSAL FOR THE MEASUREMENT OF THE REAL EMITTANCE OF THE BEAM IN CYCLIC ACCELERATORS. Chinese Physics C, 1983, 7(2): 178-185.
[20]	LUO ZI-HUA , LUO YING-XIONG , WANG LIN-LIN . STUDY OF THE BEAM TRAMSVERSE MOTION IN THE RFQ STRUCTURE. Chinese Physics C, 1982, 6(6): 688-696.

Access

Get Citation

LI Shi-Hong, JIANG Shan, HE Ming, GUAN Yong-Jing, DONG Ke-Jun, WU Shao-Yong, YUAN Yuan, MI Sheng-Quan, LIU Shu-Tian and YUAN Jian. Measurements of 41Ca in Biological Samples by AMS Using CaF2 Target[J]. Chinese Physics C, 2005, 29(12): 1210-1213.

RIS(for EndNote,Reference Manager,ProCite)

BibTex

Txt

Milestone

Received: 2005-03-04
Revised: 1900-01-01

Article Metric

Article Views(5155)
PDF Downloads(731)
Cited by(0)

Policy on re-use

To reuse of subscription content published by CPC, the users need to request permission from CPC, unless the content was published under an Open Access license which automatically permits that type of reuse.

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Measurements of 41Ca in Biological Samples by AMS Using CaF2 Target

Corresponding author: LI Shi-Hong,

Department of Nuclear Physics,Chinese Institute of Atomic Energy,Beijing 102413,China

Received Date: 2005-03-04

Accepted Date: 1900-01-01

Available Online: 2005-12-05

Abstract: For determining numbers of ⁴¹Ca labeled biological samples, the analytical method of ⁴¹Ca/⁴⁰Ca by Accelerator Mass Spectrometry (AMS) using CaF₂ target was developed at the Beijing HI-13 AMS system. ⁴¹Ca in the biological samples and ⁴¹Ca standard samples were prepared to CaF₂ with a more effective chemical separation and purification procedure. In the ⁴¹Ca AMS measurement, CaF₃^－ negative ion was extracted from ion resource, 7⁺ charge state of particles was chosen after carbon foil stripping and accelerated at 8.5MV terminal voltage. ⁴¹Ca ions were finally recorded by an 140mbar P10 gas filled multi-anode ionization chamber detector. The results showed that ⁴¹Ca and the main isobar, ⁴¹K could be clearly identified in the two-dimensional density spectra, and the interference of ⁴¹K to ⁴¹Ca was eliminated with the very low ⁴¹K counting rate. The absolute measured values of 4 standard samples with ⁴¹Ca/⁴⁰Ca in the range of 1.785×10^－8—1.750×10^－10 were in good linear relationship with the standard values (r²=0.997). After normalized with the 1.785×10^－8⁴¹Ca/⁴⁰Ca standard, the measured values of S2 and S4 standard samples were in good agreement with the nominal values, however, the measured value of S3 deviated the nominal value largely. The ⁴¹Ca/⁴⁰Ca of the biological blanks were estimated below 8.2×10^－13.

HTML

Reference (1)

Measurements of 41Ca in Biological Samples by AMS Using CaF2 Target

Abstract：

References

Access

Article Metrics

Metrics

通讯作者: 陈斌, bchen63@163.com

Email This Article