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Chinese Physics C> 2005, Vol. 29> Issue(S1) : 71-75 

Microtranslocation of Trace Element in the Olfactory Bulb of Mice after Intranasal Instillation of Fine Oxide Particle by Synchrotron Radiation X-Ray Fluorescence

  •  Laboratory for Bio-Environmental Health Sciences of Nanoscale Materials and Key Laboratory of Nuclear Analytical Techniques,Institute of High Energy Physics,CAS,Beijing 100049,China2 Graduate School of Chinese Academy of Sciences,Beijing 100049,China3 Beijing Synchrotron Radiation Laboratory,Institute of High Energy Physics,CAS,Beijing 100049,China

  • The contents and micro distribution of iron and other trace elements in the olfactory bulb after intranasal instillation were measured by synchrotron radiation X-ray fluorescence analysis (SRXRF). The mice were intranasally instilled of fine iron oxide particles (60---200nm) at a dose of 40mg/kg b ody weight. Two weeks later, the content of iron in the olfactory bulb increased 20\% compared with the control. The elevated iron was predominately concerned in the olfactory nerve (ON), granular layer (Gl) and anterior olfactory nucleus, external part (AOE), which indicated that fine iron oxide was transported to Gl via primary olfactory nerve and further translocated in AOE via secondary olfactory nerve. Moreover, in the experiment group, the levels of Ca increased 12% and Zn decreased 17%. Similarly to Fe, the higher Ca concentration was dominantly accumulated in the ON and Gl layers as well. Although the average Cu content in the control and experimental group was similar, the distribution of Cu was obviously changed due to the exposure of fine Fe2O3 particles. In the control, Cu was primarily concerned in anterior olfactory nucleus, lateral part (AOL), AOE, accessory olfactory bulb (AOB) and granule cell layer of the accessory olfactory bulb (GrA), while the Cu content in the experimental group was significantly higher in the ON, Gl and EPl layers. In conclusion,the changes of Fe, Ca, Zn, Cu levels must be, to some extent,correlate with the oxidative stress and eurodegenerative diseases.
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    [1] . Samet J M, Dominici F R, Curriero F C D et al. The NewEng. J. Med., 2000, 343(24): 1742—17492. Gauderman W J, Avol E, Gilliland F et al. The New Eng.J. Med., 2004, 351(11): 1057—10673. Wichmann H E, Spix C, Tuch T et al. Daily Mortality andFine and Ultrafine Particles in Erfurt, Germany. Part I:Role of Particle Number and Particle Mass. Health EffectsInstitute Research Report No. 98, Boston, November, 2000,1—864. Pekkanen J, Peters A, Hoek G et al. Circulation, 2002, 106:933—9385. Klot V S, Wlke G, Tuch T et al. Eur. Respir J., 2002, 20:691—7026. Penttinen P, Timonen K L, Tiittanen P et al. Eur. RespirJ., 2001, 17(3): 428—4357. CHENG Y S, Yeh H C, Guilmette R A et al. Aerosol Sci. Technol, 1996, 5: 274—2918. Oberdrster G, Finkelstein J N, Johnston C et al. Res. Rep.Health Eff. Inst., 2000, 96: 5—749. Oberdrster G, Sharp Z, Atudorei V et al. J. Tox. EnvironHealth, 2002, 65(20): 1531—154310. Dorman D C, Struve M F, James R A et al. Toxicol Appl.Pharmacol, 2001, 170(2): 79—8711. Persson E, Henriksson J, Tallkvist J et al. Toxicology, 2003,191: 97—10812. Sunderman F W Jr. Ann. Clin. Lab. Sci., 2001, 31(1):3—2413. Brenneman K A, Wong B A, Buccellato M A et al. ToxicolAppl. Phar., 2000, 169: 238—24814. Dorman D C, McManus B E, Parkinson C U et al. InhalToxicol, 2004, 16(6-7): 481—48815. Rao D B, Wong B A, McManus B E et al. Toxicol Appl.Pharmacol, 2003, 193(1): 116-2616. de Lorenzo A J D. The Olfactory Neuron and the Blood-Brain Barrier. In: Taste and Smell in Vertebrates (CIBAFoundation Symposium Series). Wolstenholme G E W,Knight J, eds. JA Churchill, Publishers, 1970, 151—17617. Fechter L D, John D L, Lynch R A. Neurotoxicology, 2002,23: 177—18318. Oberdrster G, Sharp Z, Atudorei V et al. Inhal Toxicol,2004, 16 (6-7): 437—44519. Oberdrster E. Environ Health Perspect, 2004, 112(10):1058—106220. ZHANG Z Y et al. HEP NP. 2003,27: 114—117(in Chinese)(张智勇等.高能物理与核物理，2003, 27: 114-117)21. LIU Nian-Qing, ZHANG Fang, WANG Xue-Fei et al. SpectrochimicaActa Part, 2004, B59: 255—26022. Tjlve H, Mejare C, Borg-Neczak K. Pharmacol. Toxicol,1995, 77: 23—3123. Tjlve H, Henriksson J, Tallkvist J et al. Pharmacol Toxicol,1996, 79: 347—35624. Tjlve H, Henriksson J. Neurotoxicology, 1999, 20: 181—19525. Gulyaev A E, Gelperina S E, Skidan I N et al. Pharm Res.,1999, 16(10): 1564—156926. Smith M A, Harris P L, Sayre L M et al. Proc. Natl. Acad.Sci. USA, 1997, 94: 9866—986827. SUN A Y, CHEN Y M. J. Biomed Sci., 1998, 5: 401—41428. QIAN Zhong-Ming. Prog. in Phys. Sci., 2002, 33(3): 197—203(in Chinese)(钱钟明.生理科学进展，2002, 33(3): 197-203)

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WANG Bing, FENG Wei-Yue, WANG Meng, SHI Jun-Wen, ZHANG Fang, OUYANG Hong, ZHAO Yu-Liang, CHAI Zhi-Fang, HUANG Yu-Ying and XIE Ya-Ning. Microtranslocation of Trace Element in the Olfactory Bulb of Mice after Intranasal Instillation of Fine Oxide Particle by Synchrotron Radiation X-Ray Fluorescence[J]. Chinese Physics C, 2005, 29(S1): 71-75.
WANG Bing, FENG Wei-Yue, WANG Meng, SHI Jun-Wen, ZHANG Fang, OUYANG Hong, ZHAO Yu-Liang, CHAI Zhi-Fang, HUANG Yu-Ying and XIE Ya-Ning. Microtranslocation of Trace Element in the Olfactory Bulb of Mice after Intranasal Instillation of Fine Oxide Particle by Synchrotron Radiation X-Ray Fluorescence[J]. Chinese Physics C, 2005, 29(S1): 71-75. shu
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Received: 2005-10-28
Revised: 1900-01-01
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Microtranslocation of Trace Element in the Olfactory Bulb of Mice after Intranasal Instillation of Fine Oxide Particle by Synchrotron Radiation X-Ray Fluorescence

    Corresponding author: FENG Wei-Yue,
  • Laboratory for Bio-Environmental Health Sciences of Nanoscale Materials and Key Laboratory of Nuclear Analytical Techniques,Institute of High Energy Physics,CAS,Beijing 100049,China2 Graduate School of Chinese Academy of Sciences,Beijing 100049,China3 Beijing Synchrotron Radiation Laboratory,Institute of High Energy Physics,CAS,Beijing 100049,China
  • Received Date: 2005-10-28
  • Accepted Date: 1900-01-01
  • Available Online: 2005-01-02

Abstract: The contents and micro distribution of iron and other trace elements in the olfactory bulb after intranasal instillation were measured by synchrotron radiation X-ray fluorescence analysis (SRXRF). The mice were intranasally instilled of fine iron oxide particles (60---200nm) at a dose of 40mg/kg b ody weight. Two weeks later, the content of iron in the olfactory bulb increased 20\% compared with the control. The elevated iron was predominately concerned in the olfactory nerve (ON), granular layer (Gl) and anterior olfactory nucleus, external part (AOE), which indicated that fine iron oxide was transported to Gl via primary olfactory nerve and further translocated in AOE via secondary olfactory nerve. Moreover, in the experiment group, the levels of Ca increased 12% and Zn decreased 17%. Similarly to Fe, the higher Ca concentration was dominantly accumulated in the ON and Gl layers as well. Although the average Cu content in the control and experimental group was similar, the distribution of Cu was obviously changed due to the exposure of fine Fe2O3 particles. In the control, Cu was primarily concerned in anterior olfactory nucleus, lateral part (AOL), AOE, accessory olfactory bulb (AOB) and granule cell layer of the accessory olfactory bulb (GrA), while the Cu content in the experimental group was significantly higher in the ON, Gl and EPl layers. In conclusion,the changes of Fe, Ca, Zn, Cu levels must be, to some extent,correlate with the oxidative stress and eurodegenerative diseases.

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