Translocation of Inhaled TiO2 Nanoparticles Along Olfactory Nervous System to Brain Studied by Synchrotron Radiation X-Ray Fluorescence

WANG Jiang-Xue; CHEN Chun-Ying; SUN Jin; YU Hong-Wei; LI Yu-Feng; LI Bai; XING Li; HUANG Yu-Ying; HE Wei; GAO Yu-Xi; CHAI Zhi-Fang; ZHAO Yu-Liang

Chinese Physics C> 2005, Vol. 29> Issue(S1) : 76-79

Translocation of Inhaled TiO2 Nanoparticles Along Olfactory Nervous System to Brain Studied by Synchrotron Radiation X-Ray Fluorescence

Institute of High Energy Physics, CAS,Beijing 100049,China2 Graduate School of the CAS,Beijing 100049,China

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Abstract：
Nanosized TiO₂ is widely used for cleaning air,antibacterial and decomposing organic in wastewater for its highly photocatalytic function. TiO₂ inhalation via respiratory tracts is the most common route of its exposure in industry and environment. After inhalation by human or rodents, TiO₂ can induce inflammation and pulmonary lesions, which was reported to even cause lung cancer by long-term exposure. In this paper, Synchrotron Radiation X-ray Fluorescence was employed to investigate the distribution of TiO₂ in the olfactory bulb and brain of mice after inhalation of TiO₂ particles suspension.The results showed that TiO₂ could enter the olfactory nerve layer (ON), granular cell layer of olfactory bulb (Gro), and olfactory ventricle (OV) and further the hippocampus, thalamus,and CA3 area of the brain through the olfactory nervous system.The distribution area of microsized TiO₂ was wider than that of nanosized TiO₂.

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[1]

. Ferin J, Oberd#246;rster G, Penny D P. Am. J. Respir Cell Mol Biol, 1992, 6: 5352. Donaldson K, LI X Y, MacNee W. J. Aerosol Sci., 1998,29(5): 5533. Oberd#246;rster G, Ferin J, Lehnert B E. Environ Health Perspect,1994, 102(Supp.5): 173—1794. ZHANG Q W, Kusaka Y, Donaldson K. Inhal Toxicol,2000, 12(Supp.3): 2675. Oberd#246;rster G, Sharp Z, Atudorei V et al. Inhal Toxicol,2004, 16(6-7): 4376. ZHANG Zhi-Yong, LIU Nian-Qing, LI Fu-Liang et al. HEP NP, 2003, 27(Supp.): 114(in Chinese)(张智勇，刘年庆，李福亮等.高能物理与核物理，2003, 27(增刊):114)7. ZHANG Yu-Zhi. Studies of Trace Elements and Health,2004, 21(3): 56(in Chinese)(张玉芝.微量元索与健康研究，2004, 21(3): 56)8. HUANG Yan-E. Hebei Journal of Industrial Science Technology, 2001, 18(2): 7(in Chinese)(黄艳娥.河北工业科技，2001,18(2):7)9. Oberd#246;rster G. Phil Trans R Soc Lond A, 2000, 358: 2719

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[19]	YAO Li-Shan , ZHOU En-Chen , CAI Dun-Jiu . A SYSTEMATIC STUDY OF (n, 2n) CROSS SECTION AT 14MeV. Chinese Physics C, 1987, 11(4): 533-542.
[20]	SONG Xiao-Tong , DAI You-Shan . ELECTROMAGNETIC FORM FACTORS OF (0—1/2) ELECTROMAGNETIC BOUND SYSTEM. Chinese Physics C, 1985, 9(3): 371-376.

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WANG Jiang-Xue, CHEN Chun-Ying, SUN Jin, YU Hong-Wei, LI Yu-Feng, LI Bai, XING Li, HUANG Yu-Ying, HE Wei, GAO Yu-Xi, CHAI Zhi-Fang and ZHAO Yu-Liang. Translocation of Inhaled TiO2 Nanoparticles Along Olfactory Nervous System to Brain Studied by Synchrotron Radiation X-Ray Fluorescence[J]. Chinese Physics C, 2005, 29(S1): 76-79.

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Received: 2005-10-28
Revised: 1900-01-01

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沈阳化工大学材料科学与工程学院沈阳 110142

Translocation of Inhaled TiO2 Nanoparticles Along Olfactory Nervous System to Brain Studied by Synchrotron Radiation X-Ray Fluorescence

Corresponding author: CHEN Chun-Ying,

Institute of High Energy Physics, CAS,Beijing 100049,China2 Graduate School of the CAS,Beijing 100049,China

Received Date: 2005-10-28

Accepted Date: 1900-01-01

Available Online: 2005-01-02

Abstract: Nanosized TiO₂ is widely used for cleaning air,antibacterial and decomposing organic in wastewater for its highly photocatalytic function. TiO₂ inhalation via respiratory tracts is the most common route of its exposure in industry and environment. After inhalation by human or rodents, TiO₂ can induce inflammation and pulmonary lesions, which was reported to even cause lung cancer by long-term exposure. In this paper, Synchrotron Radiation X-ray Fluorescence was employed to investigate the distribution of TiO₂ in the olfactory bulb and brain of mice after inhalation of TiO₂ particles suspension.The results showed that TiO₂ could enter the olfactory nerve layer (ON), granular cell layer of olfactory bulb (Gro), and olfactory ventricle (OV) and further the hippocampus, thalamus,and CA3 area of the brain through the olfactory nervous system.The distribution area of microsized TiO₂ was wider than that of nanosized TiO₂.

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Translocation of Inhaled TiO2 Nanoparticles Along Olfactory Nervous System to Brain Studied by Synchrotron Radiation X-Ray Fluorescence

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