Effects of Low Priming Dose of Radiation on Cell Cycle Arrest of Tumor Cells Caused by High Dose of Radiation

XIA Jing-Guang; LI Wen-Jian; WANG Ju-Fang; GUO Chuan-Ling; YANG Jian-She; GAO Qing-Xiang

Chinese Physics C> 2005, Vol. 29> Issue(2) : 201-204

Effects of Low Priming Dose of Radiation on Cell Cycle Arrest of Tumor Cells Caused by High Dose of Radiation

Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730000,China2 Graduate School of Chinese Academy of Sciences,Beijing 100049,China3 School of Life Science,Lanzhou University,Lanzhou 730000,China

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Abstract：
Effects of low priming dose of radiation on cell cycle progression in hep G2 and Hela cells are investigated. For both cell lines, cells in the G2/M phase are accumulated temporarily after 5cGy γ-ray exposing, and the proliferation of tumor cells is significantly promoted by low dose radiation. When exposing to 3Gy γ-ray, only the G2 phase arrest occurred for hep G2 cells, and both S and G2 arrest occurred for HeLa cells. In contrast to treatment with high dose of radiation, when high dose was delivered 4hr after priming dose, pretreatment facilitates the accumulation of hep G2 cells in G2/M phase, however, pretreatment don’t significantly change the cell cycle progression of HeLa cells. It is concluded that alterations of the cell cycle progression by pretreatment with low dose of radiation are dependent on the type of tumor cell lines.

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XIA Jing-Guang, LI Wen-Jian, WANG Ju-Fang, GUO Chuan-Ling, YANG Jian-She and GAO Qing-Xiang. Effects of Low Priming Dose of Radiation on Cell Cycle Arrest of Tumor Cells Caused by High Dose of Radiation[J]. Chinese Physics C, 2005, 29(2): 201-204.

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Received: 2004-06-23
Revised: 1900-01-01

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沈阳化工大学材料科学与工程学院沈阳 110142

Effects of Low Priming Dose of Radiation on Cell Cycle Arrest of Tumor Cells Caused by High Dose of Radiation

Corresponding author: XIA Jing-Guang,

Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730000,China2 Graduate School of Chinese Academy of Sciences,Beijing 100049,China3 School of Life Science,Lanzhou University,Lanzhou 730000,China

Received Date: 2004-06-23

Accepted Date: 1900-01-01

Available Online: 2005-02-05

Abstract: Effects of low priming dose of radiation on cell cycle progression in hep G2 and Hela cells are investigated. For both cell lines, cells in the G2/M phase are accumulated temporarily after 5cGy γ-ray exposing, and the proliferation of tumor cells is significantly promoted by low dose radiation. When exposing to 3Gy γ-ray, only the G2 phase arrest occurred for hep G2 cells, and both S and G2 arrest occurred for HeLa cells. In contrast to treatment with high dose of radiation, when high dose was delivered 4hr after priming dose, pretreatment facilitates the accumulation of hep G2 cells in G2/M phase, however, pretreatment don’t significantly change the cell cycle progression of HeLa cells. It is concluded that alterations of the cell cycle progression by pretreatment with low dose of radiation are dependent on the type of tumor cell lines.

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Effects of Low Priming Dose of Radiation on Cell Cycle Arrest of Tumor Cells Caused by High Dose of Radiation

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